2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (252):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-170317
    EA-89-Succinic acid
    EA-89-Succinic acid (Compound 26) is the active control of the target protein ligand EA-89 (HY-170314), which can be used for the synthesis of PROTAC .
    EA-89-Succinic acid
  • HY-164925
    ER ligand-4
    ER ligand-4 (compound 45a) is an PROTAC target protein ligand of HY-164924.
    ER ligand-4
  • HY-163563
    JYQ-173
    JYQ-173 is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194 (HY-163564).
    JYQ-173
  • HY-159662
    HSD17B13 degrader 2 3035000-69-9
    HSD17B13 degrader 2 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). HSD17B13 degrader 2 can be used for synthesis PTOTAC HSD17B13 degrader 1 (HY-159651).
    HSD17B13 degrader 2
  • HY-169182
    AK-068 2982851-09-0
    AK-068 is a STAT6 ligand, with a Ki of 6 nM and at least >85-fold binding selectivity over STAT5. AK-068 is a ligand for target protein (STAT6) for PROTAC (HY-169179).
    AK-068
  • HY-169073
    TC13172-NH-COOH
    TC13172-NH-COOH is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). TC13172-NH-COOH can be used for synthesis PROTAC MLKL Degrader-2 (HY-169072).
    TC13172-NH-COOH
  • HY-163852
    HIV-1 inhibitor-72 2801703-79-5
    HIV-1 inhibitor-72 (compound 5m) is a target protein ligand of PROTAC Vif degrader-1 (HY-163851). HIV-1 inhibitor-72 is a potent HIV-1 inhibitor.
    HIV-1 inhibitor-72
  • HY-168638
    PROTAC SOS1 ligand 1 3027977-34-7
    PROTAC SOS1 ligand 1, a BI-3406 (HY-125817) analog, is a ligand for target SOS1 protein for PROTACT SIAIS562055 (HY-168637).
    PROTAC SOS1 ligand 1
  • HY-169087
    MJBIA9836
    MJBIA9836yes PROTACLigands for target proteins can be used to synthesize PROTACMolecules, such as MS41 (HY-169086).
    MJBIA9836
  • HY-160094
    BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) 2126749-81-1
    BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol (compound 71) is a Ligands for Target Protein for PROTAC that contains a sulfonamide linker to increase the solubility of the linker-conjugate. BCN-sulfonamide-PEG2-sulfonamide-N-bis ethanol can be used to synthesize PROTACs with antitumor activity.
    BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol)
  • HY-169180
    AK-068-OH 2982851-61-4
    AK-068-OH (Compound 49) is an active control of ligand for target protein for PROTAC (HY-169179).
    AK-068-OH
  • HY-169094
    PFI-6-COOH 2768514-05-0
    PFI-6-COOH (Compound 18) is an eleven-nineteen leukemia (ENL) ligand, and can be used for synthesis of MS41 (HY-169093), an ENL PROTAC degrader.
    PFI-6-COOH
  • HY-46340
    AZD9496 deacrylic acid phenol 2173404-70-9
    AZD9496 deacrylic acid phenol is a fragment of target protein ligand of PROTAC ER Degrader-4 (HY-135309).
    AZD9496 deacrylic acid phenol
  • HY-168248
    BRM/BRG1 ligand 2 2933125-88-1
    BRM/BRG1 ligand 2 is the ligand for target protein, which can be used for synthesis of PROTAC BRM/BRG1 degrader-2 (HY-168247).
    BRM/BRG1 ligand 2
  • HY-141486A
    PROTAC PARP/EGFR ligand 1 2661609-57-8
    PROTAC PARP/EGFR ligand 1 is an active compound that can be used for the synthesis of dual PARP EGFR degraders by proteolytic targeting chimera (PROTAC) technology.
    PROTAC PARP/EGFR ligand 1
  • HY-158433
    KDM5B ligand 2
    KDM5B ligand 2 is the ligand for target protein KDM5B. KDM5B ligand 2 is utilized for synthesis of KDM5B PROTAC GT-653 (HY-158432).
    KDM5B ligand 2
  • HY-159009
    MS7 1593654-46-6
    MS7 is a potent inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). NAMPT is overexpressed in many cancer cells to meet the continuous replenishment of NAD+ required for rapid proliferation. MS7, as a NAMPT target protein ligand, can be used to synthesize PROTAC A7, which is an effective NAMPT degrader. MS7 can be used in cancer research.
    MS7
  • HY-111843
    Ch55-O-C3-NH2 144298-98-6
    Ch55-O-C3-NH2 (RAR ligand 1) is a Ch 55-based ligand, which targets RAR. Ch55-O-C3-NH2 (RAR ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
    Ch55-O-C3-NH2
  • HY-169379
    CSI118 TFA
    CSI118 TFA (Compound 1) is a Ligand for Target Protein for PROTAC. CSI118 TFA can be used to synthesize CSI86 (HY-169378).
    CSI118 TFA
  • HY-143270
    PROTAC BRD9-binding moiety 5 893633-37-9
    PROTAC BRD9-binding moiety 5 is a selective BRD9 binder with an IC50 value of 4.20 μM, can be used for the synthesis of PROTACs. PROTAC BRD9-binding moiety 5 has antiproliferative activity against cancer cells.
    PROTAC BRD9-binding moiety 5